![]() ![]() 125000003275 alpha amino acid group Chemical group 0.000 claims 4.230000002159 abnormal effect Effects 0.000 claims description 30.201000001971 Huntington's disease Diseases 0.000 claims description 44.VSUBSHMCMRUEAG-IQVZWRNHSA-N QBP1 Chemical compound VSUBSHMCMRUEAG-IQVZWRNHSA-N 0.000 claims description 54.229920000155 polyglutamine Polymers 0.000 claims description 68.230000036678 protein binding Effects 0.000 claims abstract description 32.230000014509 gene expression Effects 0.000 claims abstract description 46.102100003586 HSPA8 Human genes 0.000 claims abstract description 74.239000002157 polynucleotide Substances 0.000 claims abstract description 76.229920000023 polynucleotide Polymers 0.000 claims abstract description 76.230000004915 chaperone-mediated autophagy Effects 0.000 title description 30.230000000593 degrading Effects 0.000 title claims abstract description 14.108090000623 proteins and genes Proteins 0.000 title claims abstract description 148.102000004169 proteins and genes Human genes 0.000 title claims abstract description 148.Assignors: BAUER, PETER, NUKINA, NOBUYUKI Publication of US20100016221A1 publication Critical patent/US20100016221A1/en Status Abandoned legal-status Critical Current Links Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Application filed by RIKEN Institute of Physical and Chemical Research filed Critical RIKEN Institute of Physical and Chemical Research Priority to US12/175,211 priority Critical patent/US20100016221A1/en Assigned to RIKEN reassignment RIKEN ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Original Assignee RIKEN Institute of Physical and Chemical Research Priority date (The priority date is an assumption and is not a legal conclusion. ![]() RIKEN Institute of Physical and Chemical Research Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.) Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Abandoned Application number US12/175,211 Inventor Nobuyuki NUKINA Peter Bauer Current Assignee (The listed assignees may be inaccurate. Google Patents Method of degrading protein by chaperone-mediated autophagyÄownload PDF Info Publication number US20100016221A1 US20100016221A1 US12/175,211 US17521108A US2010016221A1 US 20100016221 A1 US20100016221 A1 US 20100016221A1 US 17521108 A US17521108 A US 17521108A US 2010016221 A1 US2010016221 A1 US 2010016221A1 Authority US United States Prior art keywords protein peptide polyq disease cells Prior art date Legal status (The legal status is an assumption and is not a legal conclusion. Google Patents US20100016221A1 - Method of degrading protein by chaperone-mediated autophagy US20100016221A1 - Method of degrading protein by chaperone-mediated autophagy ![]()
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